Christian McCaffrey (calf) likely to miss Sunday's Seahawks game

Christian McCaffrey’s calf is once again strained, a worrying update for 49ers fans and fantasy managers hoping for his participation in the season opener. Calf strains can limit a player’s explosiveness, affecting sprinting, cutting, and acceleration—key skills for a running back of McCaffrey’s caliber. Even a mild strain can reduce his ability to push off the ground, making it harder to evade tacklers or break long runs. It also increases the risk of re-injury, meaning coaches may limit his snap count or avoid high-risk plays early in the season. Ball security and catching out of the backfield may also be affected, as any hesitation in movement can disrupt timing. Recovery strategies often include targeted stretching, strengthening, and controlled practice reps to get him game-ready. Fantasy managers may need to consider alternatives for the first few weeks if his availability is uncertain.

The 49ers are expected to be cautious with McCaffrey, prioritizing long-term health over immediate impact, especially given his injury history. They may hold him out of preseason games or limit him in practice to avoid aggravating the calf. Play-calling could also be adjusted, with fewer explosive or cutting plays designed to minimize stress on his leg. The team’s medical staff will likely monitor his condition closely, using imaging and physical assessments to guide decisions. Overall, the 49ers are signaling that they will take a measured approach, ensuring McCaffrey is fully ready before putting him in high-pressure situations.